Watch patients with sickle cell disease describe their treatment experiences with ADAKVEO
ADAKVEO is a prescription medicine used in people 16 years of age and older who have sickle cell disease to help reduce how often painful crises happen. It is not known if ADAKVEO is safe and effective in children under 16 years of age.
45% vs placebo (based on a median annual rate of 1.63 pain crises with ADAKVEO vs 2.98 with placebo) in a 1-year study*
67 people taking ADAKVEO experienced a median annual rate of 1.63 pain crises‡ compared with 65 people taking placebo who experienced 2.98 pain crises—a 45% reduction. The median is the number that is exactly in the middle of all results seen in the 1-year study.
The safety and effectiveness of ADAKVEO were studied in 198 people with sickle cell disease.
67 people received ADAKVEO, and 65 people received placebo at study centers primarily across the United States.
In the 1-year study, pain crises were defined as painful episodes that led to a health care visit (ER, clinic, hospital, or local physician visit). Your doctor or health care provider may refer to pain crises as "vaso-occlusive crises" [vey-soh uh-kloo-siv] or VOCs. The following health conditions were also considered pain crises if they led to a health care visit:
*In the 1-year SUSTAIN study, the safety and effectiveness of ADAKVEO were studied in 198 people with sickle cell disease who were 16 to 63 years old. 67 people received ADAKVEO and 65 people received placebo at study centers primarily across the United States.
‡Pain crises were defined as painful episodes leading to a health care visit (ER, clinic, hospital, or local physician visit). Results were based on 132 patients with sickle cell disease who participated in a 1-year clinical study.
The clinical study of ADAKVEO included people:
Across all genotypes of sickle cell disease, including HbSS, HbSC, HbSß0-thalassemia, HbSß+-thalassemia, and others
Who were of African, Hispanic, Caucasian, and other ancestries
Who had either 2-4 or 5-10 painful episodes (crises) in the last 12 months
Who were also on hydroxyurea, and people who were not