Pain Crises Matter

Pain crises in sickle cell disease

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Prescribing Info Including Patient Info

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IMPORTANT SAFETY INFORMATION:

What is the most important information I should know about ADAKVEO?

ADAKVEO may cause serious side effects, including infusion reactions.

Infusion reactions. Infusion reactions may happen...

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Approved Use:

ADAKVEO^® (crizanlizumab-tmca) is used in people 16 years of age and older who have sickle cell disease to help reduce how often certain episodes (crises) happen. It is not known if ADAKVEO is safe and effective in children under 16 years of age....

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Every pain crisis matters

Pain crises are sudden and unpredictable episodes (crises) that can last on average 10 days.

Every pain crisis matters

Pain crises are sudden and unpredictable episodes (crises) that can last on average 10 days.

Blockages caused by sickle cell disease make it difficult for blood and oxygen to flow normally in the blood vessels. When blood flow slows or gets blocked within the blood vessel, there can be sudden, intense pain (pain crises), or other sudden complications that may require medical help

Pain crises are the leading cause of emergency room (ER) visits for people with sickle cell disease*

Pain crises are the leading cause of hospitalizations in patients with sickle cell disease^†

*National estimate of SCD-related ER visits. Data from the Nationwide Emergency Department Sample (NEDS) of 50,418 ER visits for patients with SCD in 2006.
^†Data from 182 patients with sickle cell anemia followed prospectively over 5 years at the sickle cell center of the Cardeza Foundation for Hematologic Research of Jefferson Medical College and Thomas Jefferson University Hospital, Philadelphia, from January 1998 to December 2002.

*National estimate of SCD-related ER visits. Data from the Nationwide Emergency Department Sample (NEDS) of 50,418 ER visits for patients with SCD in 2006.
^†Data from 182 patients with sickle cell anemia followed prospectively over 5 years at the sickle cell center of the Cardeza Foundation for Hematologic Research of Jefferson Medical College and Thomas Jefferson University Hospital, Philadelphia, from January 1998 to December 2002.

Four Out Of Five Pain Crises Managed At Home

It's important to speak to your health care providers regularly about your condition. Between visits, keep track of each pain crisis you have, even the ones you manage at home.

Is ADAKVEO right for you?

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Support and recognize the strength of those living with sickle cell disease, and highlight ADAKVEO as a treatment option

Next: Understanding SCD