Impact of Pain Crises in Sickle Cell Disease

IMPORTANT SAFETY INFORMATION:

What is the most important information I should know about ADAKVEO?

ADAKVEO may cause serious side effects, including infusion reactions.

Infusion reactions. Infusion reactions may happen within 24 hours of receiving an infusion of ADAKVEO. Tell your health care provider right away if you get any of the following signs and symptoms of an infusion reaction:

fever
Chills or shivering
nausea
vomiting
tiredness
dizziness
sweating
hives
itching
shortness of breath or wheezing

Your doctor or health care provider may monitor you for signs and symptoms of infusion reactions.

ADAKVEO may interfere with a blood test.

Tell your health care provider that you are receiving ADAKVEO before having any blood tests. ADAKVEO may interfere with a laboratory test to measure your platelet counts.

Before receiving ADAKVEO, tell your health care provider about all of your medical conditions, including if you

are pregnant or plan to become pregnant. It is not known if ADAKVEO may harm your unborn baby
are breastfeeding or plan to breastfeed. It is not known if ADAKVEO passes into your breast milk. You and your health care provider should decide the best way to feed your baby during treatment with ADAKVEO

Tell your health care provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of ADAKVEO include:

nausea
joint pain
back pain
fever

These are not all of the possible side effects of ADAKVEO. For more information, ask your health care provider or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information, including Patient Information.

Approved Use:

ADAKVEO^® (crizanlizumab-tmca) is used in people 16 years of age and older who have sickle cell disease to help reduce how often certain episodes (crises) happen. It is not known if ADAKVEO is safe and effective in children under 16 years of age.

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Prescribing Info Including Patient Info

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IMPORTANT SAFETY INFORMATION:

What is the most important information I should know about ADAKVEO?

ADAKVEO may cause serious side effects, including infusion reactions.

Infusion reactions. Infusion reactions may happen...

See More

Approved Use:

See More

IMPORTANT SAFETY INFORMATION:

What is the most important information I should know about ADAKVEO?

ADAKVEO may cause serious side effects, including infusion reactions.

fever
Chills or shivering
nausea
vomiting
tiredness
dizziness
sweating
hives
itching
shortness of breath or wheezing

Your doctor or health care provider may monitor you for signs and symptoms of infusion reactions.

ADAKVEO may interfere with a blood test.

Tell your health care provider that you are receiving ADAKVEO before having any blood tests. ADAKVEO may interfere with a laboratory test to measure your platelet counts.

Before receiving ADAKVEO, tell your health care provider about all of your medical conditions, including if you

are pregnant or plan to become pregnant. It is not known if ADAKVEO may harm your unborn baby
are breastfeeding or plan to breastfeed. It is not known if ADAKVEO passes into your breast milk. You and your health care provider should decide the best way to feed your baby during treatment with ADAKVEO

Tell your health care provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

The most common side effects of ADAKVEO include:

nausea
joint pain
back pain
fever

These are not all of the possible side effects of ADAKVEO. For more information, ask your health care provider or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information, including Patient Information.

Approved Use:

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Every pain crisis matters

Pain crises are sudden and unpredictable episodes (crises) that can last on average 10 days.

Every pain crisis matters

Pain crises are sudden and unpredictable episodes (crises) that can last on average 10 days.

Blockages caused by sickle cell disease make it difficult for blood and oxygen to flow normally in the blood vessels. When blood flow slows or gets blocked within the blood vessel, there can be sudden, intense pain (pain crises), or other sudden complications that may require medical help

Pain crises are the leading cause of emergency room (ER) visits for people with sickle cell disease*

Pain crises are the leading cause of hospitalizations in patients with sickle cell disease^†

*National estimate of SCD-related ER visits. Data from the Nationwide Emergency Department Sample (NEDS) of 50,418 ER visits for patients with SCD in 2006.
^†Data from 182 patients with sickle cell anemia followed prospectively over 5 years at the sickle cell center of the Cardeza Foundation for Hematologic Research of Jefferson Medical College and Thomas Jefferson University Hospital, Philadelphia, from January 1998 to December 2002.

*National estimate of SCD-related ER visits. Data from the Nationwide Emergency Department Sample (NEDS) of 50,418 ER visits for patients with SCD in 2006.
^†Data from 182 patients with sickle cell anemia followed prospectively over 5 years at the sickle cell center of the Cardeza Foundation for Hematologic Research of Jefferson Medical College and Thomas Jefferson University Hospital, Philadelphia, from January 1998 to December 2002.

Four Out Of Five Pain Crises Managed At Home

It's important to speak to your health care providers regularly about your condition. Between visits, keep track of each pain crisis you have, even the ones you manage at home.