ADAKVEO is the first and only FDA-approved, once-monthly medication to reduce the number of pain crises in sickle cell disease*

67 people receiving ADAKVEO experienced a median annual rate of 1.63 pain crises compared with 2.98 pain crises in 65 people taking placebo—a 45% reduction. The median is the number that is exactly in the middle of all results seen in the 1 year study.

67 people taking ADAKVEO experienced a median annual rate of 4.0 days in the hospital vs 6.87 days for 65 people taking placebo—a 42% reduction. The median is the number that is exactly in the middle of all results seen in the 1-year study. The annual number of days a patient was hospitalized included those days related to pain crises.

 

*You will be given the first IV infusion at Week 0 and the second IV infusion 2 weeks later (Week 2). After that, you will be given an IV infusion every 4 weeks.

Pain crises were defined as painful episodes leading to a health care visit (ER, clinic, hospital, or local physician visit). The following health conditions were also considered pain crises if they led to a health care visit: respiratory issues, or acute chest syndrome; reduced blood flow or cell trapping in the liver, or hepatic sequestration; reduced blood flow or cell trapping in the spleen, or splenic sequestration; prolonged erections, or priapism. Results were based on 132 patients with sickle cell disease.

 

Possible side effects of ADAKVEO

ADAKVEO may cause serious side effects, including infusion reactions. Infusion reactions may happen within 24 hours of receiving an infusion of ADAKVEO. Tell your health care provider right away if you get any of the following signs and symptoms of an infusion reaction:

Your health care provider may monitor you for signs and symptoms of infusion reactions.

 

ADAKVEO may interfere with a blood test. Tell your health care provider that you are receiving ADAKVEO before having any blood tests. ADAKVEO may interfere with a laboratory test to measure your platelet counts.

 

The most common side effects of ADAKVEO include: nausea, back pain, joint pain, and fever.

 

Talk to your doctor to see if ADAKVEO is right for you.

 

Please see additional Important Safety Information.

 

How will you receive ADAKVEO?

ADAKVEO is a 30-minute IV infusion given once per month by a health care professional

You will be given the first IV infusion at Week 0 and the second IV infusion 2 weeks later (Week 2). After that, you will be given an IV infusion every 4 weeks. If you miss an appointment for infusion, contact your doctor or health care provider as soon as possible to reschedule.