IMPORTANT SAFETY INFORMATION:

What is the most important information I should know about ADAKVEO?

ADAKVEO may cause serious side effects, including infusion reactions.

Infusion reactions. Infusion reactions may happen within 24 hours of receiving an infusion of ADAKVEO. Tell your health care provider right away if you get any of the following signs and symptoms of an infusion reaction:

  • fever
  • chills or shivering
  • nausea
  • vomiting
  • tiredness
  • dizziness
  • sweating
  • hives
  • itching
  • shortness of breath or wheezing

Your doctor or health care provider may monitor you for signs and symptoms of infusion reactions.

 

ADAKVEO may interfere with a blood test. 

 

Tell your health care provider that you are receiving ADAKVEO before having any blood tests. ADAKVEO may interfere with a laboratory test to measure your platelet counts.

 

Before receiving ADAKVEO, tell your health care provider about all of your medical conditions, including if you

  • are pregnant or plan to become pregnant. It is not known if ADAKVEO may harm your unborn baby
  • are breastfeeding or plan to breastfeed. It is not known if ADAKVEO passes into your breast milk. You and your health care provider should decide the best way to feed your baby during treatment with ADAKVEO

Tell your health care provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

 

The most common side effects of ADAKVEO include:

  • nausea
  • joint pain
  • back pain
  • fever

These are not all of the possible side effects of ADAKVEO. For more information, ask your health care provider or pharmacist.

 

Call your doctor for medical advice about side effects.

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

 

Please see full Prescribing Information, including Patient Information.

 

What is ADAKVEO® (crizanlizumab-tmca)?

 

Approved Use:

ADAKVEO is used in people 16 years of age and older who have sickle cell disease to help reduce how often certain episodes (crises) happen. It is not known if ADAKVEO is safe and effective in children under 16 years of age.

LEARN ABOUT

Pain crises in sickle cell disease

Pain crises, also known as "vaso-occlusive crises" [vey-soh uh-kloo-siv] or VOCs, in sickle cell disease are unpredictable, sudden, and intense episodes of pain that can last 10 days on average. Pain crises or other sudden complications may require medical help. 

Learn More
LEARN ABOUT

Treatment with ADAKVEO

Discover how ADAKVEO may play a role in managing pain crises in sickle cell disease.

LEARN MORE

*Pain crises were defined as painful episodes leading to a health care visit (ER, clinic, hospital, or local physician visit). Results were based on 132 patients with sickle cell disease. The median is the number that is exactly in the middle of all results seen in the 1-year study.