Side Effects

Understanding the safety profile of ADAKVEO® (crizanlizumab-tmca)

What should you know about the side effects of ADAKVEO?

It’s only natural to have concerns about side effects when starting a new treatment. ADAKVEO® (crizanlizumab-tmca) may cause side effects that you are not familiar with. It's important for you and your health care provider to be aware of possible side effects of treatment with ADAKVEO.

 

 

ADAKVEO may cause serious side effects, including infusion reactions. Infusion reactions may happen within 24 hours of receiving an infusion of ADAKVEO. Your doctor or health care provider may monitor you for signs and symptoms of infusion reactions. Tell your health care provider right away if you get any of the following signs and symptoms of an infusion reaction:

 

 

  • Fever
  • Chills or shivering
  • Nausea (feeling sick)
  • Vomiting
  • Tiredness
  • Dizziness
  • Sweating
  • Hives
  • Itching
  • Shortness of breath or wheezing

 

 

ADAKVEO may interfere with a certain blood test.

 

Tell your health care provider that you are receiving ADAKVEO before having certain blood tests. ADAKVEO may interfere with a laboratory test to measure your platelet counts.

 

 

Common Side Effects

The most common side effects of ADAKVEO include nausea, back pain, joint pain, and fever. In the ADAKVEO study, most side effects were mild to moderate.

 

These are not all of the possible side effects of ADAKVEO. For more information, ask your health care provider or pharmacist. Call your doctor or health care provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Some Helpful Tips

As a person living with sickle cell disease, it's important to take care of yourself. Whether you are currently receiving ADAKVEO or not, follow these general tips for staying healthy:

Eat heart-healthy foods such as fruits, vegetables, whole grains, and protein-rich foods, and drink 8 to 10 glasses of water a day 
Try to avoid very hot or very cold temperatures
Wash your hands regularly
Stay up-to-date with vaccinations (shots)